28 February 2024 22:52
Topic starter
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Does microdosing with truffles make sense?
Microdosing psychedelic substances such as LSD and psilocybin is often promoted, but most scientific studies show that the dosages mentioned as microdosing do not work significantly better than a placebo. So no, microdosing does not work better than a placebo. This is likely because most people dose too low.
However, microdosing with truffles or LSD can be beneficial if the dosage exceeds a threshold. In that case, microdosing can help take the edge off and reduce symptoms. The effect of microdosing then resembles that of antidepressants. It is important to know that microdosing is not only intended to suppress symptoms, but also to facilitate change.
Based on our experience, we can say that the best results are achieved with stronger trips and more time between trips than with long-term microdosing. See also our information:
Microdosing acts as a placebo | Microdosing via Triptherapie
1 Answer
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11 September 2025 13:51
Microdosing with truffles can can be meaningful, but their usefulness depends heavily on your goal, dosage, body type, and neurochemistry. Practical experience and scientific insights paint a nuanced picture: it by no means always works, and certainly not for everyone.
Science shows that classical microdosing (such as 0.5 to 1 gram of fresh truffles) often do not work significantly better than a placebo. This is because enzymes such as MAO (monoamine oxidase) usually break down the active substances psilocybin and psilocin at such low doses before they reach the brain. In that case, the microdose no longer has a physiological effect, and only the placebo effect remains.
However, there are situations in which microdosing with truffles meaningful can be. For example:
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For anxiety disorders or PTSD Microdosing can be a gentle and accessible way to get used to psychedelics, without overwhelming effects. You can read more about it in this topic about microdosing for PTSD.
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As temporary mood regulation: through mild stimulation of serotonin receptors, feelings of gloom or stress can temporarily decrease, offering an opening to break patterns.
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As support for lifestyle changes: Triptherapie recommends microdosing as part of a broader approach, including lifestyle coaching, nutrition, and supplements, such as with the kickstarter program for microdosing.
The common thread here is that microdosing is most effective and beneficial when the dosage is just above the threshold and when combined with reflection, coaching, and a healthy lifestyle. However, for many users, the effect diminishes after a few weeks due to tolerance, and a break of 1-2 weeks can often restore this.
If you want to find out whether microdosing is beneficial in your situation, you can take the no-obligation intake for Triptherapie fill in. You will then receive personalized advice based on your health, goals, and preferences.