[Solved] Can Atarax be combined with psilocybin?

Yes, in principle you can take magic mushrooms or truffles if you hydroxyzine (Atarax) used, but the combination can affect the experience of the trip.

Hydroxyzine is a H1 antihistamine with calming and mildly anxiety-reducing properties. It blocks the action of histamine in the brain, which leads to drowsiness, reduced sensory acuity and lower alertness. This causes the operation of psilocybin not blocked like with benzodiazepines, but weakened.

During a psilocybin or truffle session hydroxyzine often causes:

• Fewer visual effects
• Less intense emotional experience
• More calmness, less chance of panic
• Drowsiness or sleepiness

The reason is that psilocybin expands consciousness via serotonin (5-HT2A receptors), while hydroxyzine dampens brain activity via histamine receptors. That combination can the reduce the depth and clarity of a psychedelic experience, which is sometimes desirable (for example, in the case of anxiety disorders), but it can also reduce the therapeutic value.

For some people, this feels safer. Others, however, experience the trip as “flat” or less insightful. If you want a deep, transformative psilocybin session If you are considering this, it may be better to temporarily stop taking hydroxyzine — in consultation with your doctor. 

The half-life of hydroxyzine (Atarax) lies between the 14 and 25 hours, depending on factors such as age, liver function, and individual metabolism.

That means it takes a day on average. takes before half of the active substance is broken down in your body. Complete elimination (where >95% is out of your system) usually takes 4 to 5 times the half-life, so about 3 to 5 days.

If you wish to temporarily pause hydroxyzine prior to a psilocybin experience, it is advisable to do so for at least 4 days in advance to do. This must always be done in consultation with your doctor — especially if you are using it for anxiety, allergies, or sleep problems.

Today, someone took Atarax about 24 hours before her psilocybin trip. It does not appear that the effects of psilocybin have been dampened. However, this woman is somewhat more restless than the average person. Since this is only one case and the woman in question has ADHD, no firm conclusions can be drawn. The restlessness could be due to the ADHD, and the normal strength of psilocybin could also be due to personal sensitivities.