6 April 2024 12:29
Topic starter
2
Can someone who uses Ozempic have a psilocybin session?
Ozempic contains the active ingredient semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. It works by binding to and stimulating the activity of GLP-1 receptors. Psilocybin works after conversion to psilocin acts on entirely different receptors, specifically the 5HT receptors, than Ozempic and therefore has no direct interactions. Ozempic (Rybelsus) is therefore not a contraindication for the use of psilocybin, psilocybin-containing magic mushrooms, or magic truffles.
However, people with diabetes should monitor their blood sugar levels while using psilocybin. This is because less food is consumed around the psilocybin session, and changes in brain activity and/or stress responses may lead to increased glucose usage. We can check blood sugar levels occasionally and administer dextrose if necessary.
More about: Psilocybin session | Psilocybin
2 Answers
1
14 November 2025 18:31
Yes, someone who uses Ozempic (active ingredient: semaglutide) can in principle a psilocybin session do so, provided that a few important points are taken into account.
No direct interaction with psilocybin:
Ozempic acts via GLP-1 receptors and influences blood sugar levels, insulin release, and the feeling of satiety. Psilocybin, on the other hand, acts (after conversion to psilocin) via serotonin receptors, primarily the 5-HT2A receptor. Therefore, there is no pharmacological overlap or direct interaction between these substances.
Be careful with diabetes:
Because Ozempic is often used by people with type 2 diabetes, it is essential to be extra vigilant about blood sugar levels around a psychedelic session. During such a session, less is usually eaten, and due to altered brain activity, your body may handle glucose differently. This can lead to hypoglycemia, especially if you are also using other blood sugar-lowering medications.
At Triptherapie, this is handled with care: measuring your blood sugar level during the session is possible and can be done by the supervising therapist. If necessary, dextrose can be administered immediately. The combination of medical alertness and experience makes it safe to undergo a session.
Preparation is crucial:
To ensure everything is properly coordinated, it is important that you accurately state your health condition and medication use in the intake for trip therapy. This way, your facilitator can ensure a session that is both therapeutically valuable and physically safe.
In short: using Ozempic need not be an obstacle to a truffle session or a psilocybin session, provided you are under proper supervision and your health has been properly assessed beforehand.
Did you know, by the way?
That psilocybin possibly bhas protective effects on pancreatic cells?
2
3 November 2025 12:37
Thanks to Marcel for this excellent and detailed explanation of semaglutide and psilocybin.
What I would like to add is a practical perspective on what Marcel said about blood sugar monitoring. This is indeed essential, but the reasoning behind it deserves a bit more nuance.
On average, we see that people with diabetes who use psilocybin in therapeutic settings generally respond well—the therapist's attention and careful preparation ensure that risks are minimized. Semaglutide itself is actually beneficial because it helps keep blood sugar stable.
The crucial moment, however, is the first 3-4 hours after psilocybin intake, when:
1. Metabolism changes due to the psychedelic effect
2. Reducing food intake (as Marcel said) can lower blood sugar
3. Emotional release, endorphins, and glucose consumption can change
So Marcel's offer to check blood sugar AND have dextrose on hand is EXACTLY what you want to hear. This means you are in safe hands.
My tip for preparation: work with your endocrinologist (diabetologist) AND your psilocybin therapist. Give both of them all the information. Your endocrinologist can help you properly regulate your blood sugar levels in the weeks leading up to your session. This provides a stable baseline that allows Marcel to work better.
This is a very good example of how somatic conditions are NOT a contraindication for psychedelic therapy – as long as you are well prepared and have professional supervision!