[Solved] Can Lamotrigine be taken with psilocybin or LSD?

Lamotrigine is a mood stabilizer and anti-epileptic, often prescribed for bipolar disorder or epilepsy. It works primarily by regulating glutamate and other neurotransmitters, and may potentially dampen the intensity of psychedelic substances — especially psilocybin and LSD. Various reports indicate that Lamotrigine increases the psychedelic effects. flattens, which can lead to a less deep or even incoherent trip. With LSD, the sedative effects seem to be even stronger than with psilocybin.

More importantly: in bipolar disorders, the use of psychedelics is not recommended, unless this occurs under highly expert supervision, such as during clinical research or within a controlled therapy protocol. Despite their therapeutic potential, LSD and psilocybin can trigger manic or psychotic episodes in people with a predisposition to mood disorders.

On a case-by-case basis, a psychiatrist must assess whether bipolar disorder and a psychedelic session can be combined and what precautions need to be taken. For instance, we are aware of cases where a psychiatrist deliberately prescribed Lamotrigine for a psychedelic session. The psychiatrist stated that this was to limit the risk of mania or psychosis and to make the subjective experience less intense, while the psychedelic could still perform its function on another level.