Can sumatriptan be taken with truffles (psilocybin)?

Can Sumatriptan be taken with truffles?

Sumatriptan is a medication used to treat migraine. It acts primarily on the 5-HT1B/1D receptors in the blood vessels of the brain, causing the blood vessels to constrict and relieving the migraine attack.

Psilocin, the active metabolite of psilocybin (the active ingredient in truffles), acts on various serotonin receptors in the brain. It has the highest affinity for the 5-HT2A receptor, which is involved in the regulation of mood, perception, and cognition. Psilocin also affects the 5-HT2B and 5-HT1A receptors.

Although both substances act on approximately serotonin receptors, they have different effects on the brain. Combining sumatriptan and other triptans with truffles is discouraged because, firstly, there is little research available regarding the safety of the combination. Secondly, sumatriptan can cause serotonin receptors to become occupied, making psilocybin/psilocin less effective.

To prevent possible interactions between psilocybin and sumatriptan, it is often sufficient to refrain from taking sumatriptan for a day prior to a psilocybin treatment. The half-life of sumatriptan varies, but it is generally estimated at approximately 2 hours. This means that after about 2 hours, half of the ingested sumatriptan dose has disappeared from the body.

Always ask your own doctor what the best option is in your case and whether skipping medication for one day is sufficient for you, as there is some variation in half-lives due to differences in age, liver and kidney function.

More info: Truffles and medication | Truffle session