29 May 2025 08:02
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Can truffles or psilocybin be taken together with Bellozal (histamine medication)?
2 Answers
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29 May 2025 08:30
Based on current knowledge and pharmacological properties, no direct interactions are known between truffles or psilocybin and Bellozal® (bilastine). Bilastine is an antihistamine that acts highly selectively on the H₁ receptor and barely crosses the blood-brain barrier. Psilocybin, on the other hand, exerts its psychedelic effect via the serotonin 5-HT₂A receptor. Therefore, there is no overlap in their mechanisms of action.
Pharmacokinetically, interactions are also unlikely. Bilastin is largely excreted unchanged via urine and feces and is not dependent on the CYP450 enzyme system. Psilocybin is converted to psilocin, which is broken down via glucuronidation and MAO-A. Even if psilocin slightly inhibits CYP enzymes, this has no effect on bilastin because it is removed from the body via other mechanisms of action.
If you want to be absolutely certain that both substances are not simultaneously active in your body, you can use the rule of thumb of five times the half-life of 14.5 hours. For bilastine, this means a waiting period of approximately three days (72.5 hours) for complete elimination. You can restart the medication one day after using psilocybin, as the body will then have almost completely broken down psilocybin and psilocin into inactive metabolites.
In concrete terms: the use of Bellozal need not be an obstacle to a truffle ceremony or psilocybin session, unless you have specific medical factors such as liver or kidney problems or medication sensitivity. If in doubt, it is always wise to discuss this with your doctor.
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29 May 2025 08:37
Psilocybin Bellozal antihistamine interaction
In general, the same applies to other H₁ antihistamines: there are no known clinically relevant interactions with psilocybin/psilocin, because:
Various metabolic pathways
- Psilocin is primarily formed by dephosphorylation of psilocybin and subsequently largely degraded via glucuronidation (UGT1A9, UGT1A10) and MAO-A..
- Most antihistamines are either excreted unchanged (cetirizine, fexofenadine) or cleared via CYP enzymes (loratadine, diphenhydramine). There is hardly any overlap with UGT or MAO-A pathways, so the risk of pharmacokinetic interactions is very low.
Limited pharmacodynamic overlap
- Antihistamines block H₁ receptors; psilocin acts as an agonist/partial agonist on 5-HT₂A (and some other 5-HT subtypes).
- Only with first-generation agents (e.g., diphenhydramine) can central sedation and anticholinergic side effects unexpectedly influence the subjective experience of a trip.
5× t₁/₂' for complete elimination
| Antihistamine | Generation | Metabolism | t₁/₂ | 5 × t₁/₂ |
|---|---|---|---|---|
| Cetirizine | 2nd | virtually unchanged via kidney (≥ 80 % unchanged) | 8.3 hours | ≈ 41.5 hours (~ 2 days) |
| Loratadine | 2nd | CYP3A4 & CYP2D6 → desloratadine (active) |
8 hours (3–20 hours) |
≈ 40 hours (~ 1.7 days) for older material;≈ 135 hours (~ 5.6 days) for desloratadine |
| Fexofenadine | 2nd | < 5 % via hepatic (OATP2B1/P-gp) |
14.4 hours |
≈ 72 hours (~ 3 days) |
| Diphenhydramine | 1st | CYP2D6, CYP1A2, CYP2C9, CYP2C19 |
median 4.3 hours (2.4–9.3 hours) |
≈ 21.5 hours (~ < 1 day) |
Tip: If you absolutely want to strictly avoid both substances occurring together in your system, you can only combine the substances in question after the longest '5× t₁/₂' period in the diagram above.
Conclusion:
- Clinically relevant interactions between psilocybin/psilocin and all common H₁ antihistamines are not plausible.
- For first-generation drugs, however, the sedative and anticholinergic side effects can modulate the trip experience.
- In case of doubt or personal risk factors (liver/kidney function, psychiatric history), always consult the prescribing physician.