28 April 2025 23:40
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Is it true that you experience fewer visual effects from truffles if you take a dose of MDMA with them? I actually had almost no visuals with 75mg of MDMA and 20 grams of truffles. Does MDMA inhibit psilocybin?
1 Answer
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28 April 2025 23:50
MDMA can indeed weaken the visual effects of psilocybin (truffles). The main reasons for this are:
MDMA primarily activates serotonin release in a way that enhances euphoria, empathy, and energy, but it also influences how receptors respond to psychedelics such as psilocybin.
Psilocybin acts primarily as a 5-HT2A receptor agonist to cause those typical hallucinations and visual distortions. MDMA, however, already "occupies" part of the serotonin system (and can indirectly temporarily reduce the sensitivity of those receptors).
The combination (""hippie flip"") emphasizes feelings of love, connection, and physical euphoria rather than strong visual changes or deep hallucinations.
With 75 mg of MDMA, you are at a light to moderate dose (especially when compared to a usual dose of 100-125 mg), and 20 grams of fresh truffles is normally a substantial dose (comparable to around 3-4 grams of dried magic mushrooms). Nevertheless, the MDMA can change the character of the trip towards empathy and reduced visual intensity.
Briefly summarized:
Yes, MDMA can partially "counteract" psilocybin in terms of visuals.
You usually have fewer visual and more emotionally euphoric experiences.
At higher doses of MDMA (e.g., above 100 mg), the effect could be even stronger: the psychedelic side is then suppressed even more.
If you want more visuals, timing and dosage are important. If you let the effects of psilocybin kick in sooner, the visual effects will be stronger than if you let MDMA take effect first. Naturally, a higher dose of psilocybin also results in more hallucinations.
If you want to place more emphasis on the visuals in the future, you could consider the following:
- Taking truffles and MDMA at different times (for example, MDMA only 15 minutes or longer after the truffles).
- Keep the MDMA dose even lower (for example, 50 mg).
- Increase the psilocybin dosage.
- A pure psilocybin session consider without combinations (Read more about psilocybin sessions here).
If you would like to explore how to design an optimal experience, you can also always schedule a no-obligation intake via this intake for trip therapy.