What dosage of truffles can I handle if I already have experience with cannabis, truffles, magic mushrooms, 2CB, LSD, MDMA, alcohol, ketamine, cocaine, speed, rapé, sananga, and kambo?
If you already have experience with various psychedelics and other drugs, you can probably handle a higher dose of truffles than someone who has no experience. Due to your experience with truffles, magic mushrooms, 2CB, and LSD, you likely already know what it is like to experience strong visual effects (hallucinations) and you know how to deal with them. Consequently, you are expected to be able to handle a high dose of truffles.
Furthermore, it is good to consider what you would like to achieve with a new truffle trip. If such a truffle session is intended solely for spacing out or hallucinating, then the combination of truffles and LSD (Wizardflip) might be interesting, as this combination produces many visual effects. If you wish to do it as therapy, then a high dose of truffles under the guidance of a therapist might help you further. So, think carefully about the goal of the new psychedelic journey and let us know. Also indicate which trip level you have already reached to the maximum. Read more about these topics via the links.
More info: Truffle session | Wizardflip | Triple sheets

Based on your extensive experience, you can indeed handle a higher dose of truffles. However, there are some important aspects that go beyond mere dosage.
Given your poly-drug experience, you already have a good understanding of how your body and mind react to various psychoactive substances. This is a great advantage. However, truffles/psilocybin work fundamentally differently from stimulants such as cocaine and speed. They also work differently from dissociatives like ketamine.
Regarding dosage: Research shows that for therapeutic purposes, 20-25mg of psilocybin is typically used per session, while recreational experiences often amount to 10-20mg. In grams of truffles, this translates to approximately 7-15 grams for therapeutically intense work. Much depends on the truffle species (Psilocybe cubensis, tampanensis, mexicana, etc.) and their psilocybin concentration. With Triptherapie, the dosage is often higher, namely between 25 and 45mg of psilocybin.
I read from users who have tried many drugs that they state: the more experience you have with psychedelics, the more you can handle. Look at https://tripforum.nl/recensies-ronald/psilocybine-sessie-hoge-dosering-met-ronald - someone with extensive drug experience who took a high dose of psilocybin under the guidance of therapist Ronald. The positive results were profound: emotional release, insight into deeper traumas, a transformation without panic despite the intensity.
Here is another high dosage in the review. https://tripforum.nl/recensie-truffel-therapie-marcel/hoge-dosering-truffelsessie. Here, someone described a high-dose truffle session in which they had experiences from universal unity and love. This demonstrates that higher doses are not merely 'more the same,' but can reveal qualitatively different experiences.