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Why Triptherapie can already offer legal LSD sessions with trained therapists In the Netherlands, classical LSD (lysergic acid diethylamide) is a List I substance under the Opium Act; possession, use, and trade are prohibited. Yet, more and more people are wondering whether psychedelics can play a role in thera...

There is a scientific paper that examines how increasing oral doses of psilocybin behave in the body in healthy adults. In it, it discusses: The researchers conducted an open-label dose escalation study in 12 healthy adults. The participants were given in a co...

There is a scientific paper that examines how psilocybin affects different levels of auditory information processing in healthy volunteers. In it, it discusses: The researchers used psilocybin as a serotonergic model of psychosis to see what happens to spe...

There is a scientific paper examining whether escitalopram, a widely used SSRI, alters the acute effects of psilocybin. In it, it discusses: The researchers conducted a randomised, double-blind, placebo-controlled crossover study in healthy volunteers. The dee...

There is a new scientific paper examining whether psilocybin can reduce the number of attacks in chronic cluster headaches, and whether that is related to changes in brain connectivity. In it, it discusses: The researchers conducted a small open-label clinical trial in...

There is a new scientific paper exploring how psilocybin affects blood flow to the brain, and what role the 5-HT2A receptor may play in it. In it, it discusses: The researchers compared the acute effects of psilocybin and ketanserin in a single-blind cros...

There is a new scientific article examining whether one treatment with MM120, a clinical formulation of lysergide, can reduce anxiety symptoms in people with generalised anxiety disorder. It discusses: The researchers conducted a phase 2b, multicentre, randomised...

There is a new scientific paper that for the first time directly compares the acute effects of MDMA and MDA, along with two experimental prodrug variants. In it, it discusses: The researchers conducted a double-blind, randomised, placebo-controlled crossover study u...

There is a new scientific paper that examines whether the content of the first integration conversation after a psilocybin session can say something about the likelihood of abstinence in alcohol addiction. It discusses: The researchers analysed the first integration sessions from the Psilocybin Al...

There is a new scientific paper exploring how psilocybin changes the brain's electrical activity, and how those changes are related to what people subjectively feel during the experience. In it, it discusses: The researchers conducted a double-blind, randomised...

There is a new scientific paper exploring whether psilocybin-assisted psychotherapy can also help against anhedonia, i.e. reduced ability to feel pleasure, in people with therapy-resistant depression. In it, we discuss: Anhedonia is a core symptom of depression and re...

There is a new scientific paper exploring whether short-acting psychedelic treatment with DMT can help people with moderate to severe depression. It discusses: The researchers conducted a phase 2a, double-blind, randomised, placebo-controlled study ...

There is a new scientific paper exploring how participants experience therapeutic touch during psilocybin-assisted therapy. It discusses: The authors wanted to better understand what touch during a psychedelic session means to participants. In practice w...

There is a new scientific paper looking at the effects of LSD microdosing in people with depression, with a special focus on mood, subjective perception and pharmacokinetics. It discusses: The researchers conducted an open-label phase 2a study in 19 people me...

There is a new scientific paper that examines how the acute experience of psilocybin is linked to positive effects that can be felt even weeks later. In it, it discusses: The researchers conducted a double-blind, placebo-controlled crossover study with 40 healthy free-wi...

There is a new scientific paper exploring how lifetime use of various psychedelics is related to the severity of opioid use disorder. It discusses: The authors used data from the 2023 US National Survey on Drug Use and Health, with infor...

There is a new scientific article that looks at which psychedelic treatments are currently the best researched for PTSD, and the risks and limitations involved. It discusses: The authors conducted a systematic review to see which psychedelics are the mee...

There is a new scientific paper that looks at whether psychedelics might have a role within child and adolescent psychiatry in the future. In it, they discuss: The authors explain that there is renewed interest in substances such as psilocybin, LSD, MDMA, ketamine and ...