The "baselines" of your neurotransmitters essentially determine the lens through which you view the psychedelic experience. Although psilocin is the protagonist, the other substances present set the scene.
Here is how the key neurotransmitters can color the session:
GABA is the most important inhibitory neurotransmitter. It provides calm and clarity.
In case of a shortage: If your GABA levels are too low, a psychedelic session can be experienced more quickly as "chaotic" or overwhelming. The influx of new stimuli is then not properly filtered, which can lead to panic or a feeling of loss of control.
Optimal status: There is a foundation of calmness, allowing you to observe the visual and emotional changes with curiosity rather than fear.
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Glutamate is the counterpart to GABA and causes excitation (activation). Psychedelics increase glutamate release in the prefrontal cortex.
In case of an excess: This can lead to thought loops or an overstimulated nervous system.
Optimal status: It provides sharpness and deep insights. It is the fuel for the new connections that are being formed.
Dopamine powers our focus and sense of meaning.
In case of a shortage: A session can feel "empty," or it is difficult to translate the insights gained into motivation for change in daily life.
Optimal status: A deep sense of euphoria and "aha moments" arises. You feel the urgency and the power to actually restructure your life after the session.
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This material is crucial for learning ability and information retention.
In case of a shortage: You have a wonderful experience, but the next day it feels like a dream slipping away. The details and the logic of the insights are difficult to hold onto.
Optimal status: Clear visual images and an excellent memory for what happened during the trip, which makes integration much easier afterwards.
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By testing beforehand, you can see, for example: "Ah, this person is very low in GABA and high in glutamate." Instead of going straight into the session (with the risk of an anxious experience), you can first work on restoring that balance for two weeks with specific foods or supplements (such as magnesium or L-theanine).
This way you prepare not only the spirit ahead of the message, but make sure that it biological receiver (your brain) is well tuned to be able to receive and process the message.
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