Can you continue using Lexapro if you want to have a psilocybin session?
Caution is advised when combining Lexapro (escitalopram) with psilocybin, the active ingredient in magic mushrooms and truffles. Lexapro is a selective serotonin reuptake inhibitor (SSRI) and affects serotonin levels in the brain. Psilocybin also affects serotonin receptors. It is important to note that there is still limited scientific research into the interaction between
SSRIs and psilocybin.
However, recent research has shown that there is no increased risk of complications, such as serotonin syndrome, when using SSRIs for a truffle session. According to that research, psilocybin truffles can be used while also taking SSRIs, including Lexapro.
However, it is important to discuss this with your treating physician, as they have the best insight into your specific situation. You can discuss whether tapering off Lexapro, and thereby achieving a stronger effect from the psilocybin session, is more important than the withdrawal symptoms caused by tapering off the SSRI.
A choice must be made from the following three options, because a psilocybin session is less effective if withdrawal symptoms are present, such as dizziness, nausea, headache, fatigue, mood swings, or electric shocks:
1. No psilocybin session, but choose other forms of therapy (EMDR, CBT, etc.).
2. Continue taking the SSRI medication and accept the potential reduced effect of psilocybin, or try a higher dosage during a possible second psilocybin session.
3. Taper off the SSRI (in consultation with a doctor) and have a psilocybin session after the withdrawal phase.
It is always important to ask your treating physician for advice regarding your specific situation. At Triptherapie, we do not provide medical advice, but you can discuss our non-medical suggestions.