5 August 2024 20:33
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Is a truffle session safe in combination with amlodipine?
19 August 2024 12:22
Is a truffle session safe in combination with amlodipine?
The combination of truffles (psilocybin) with amlodipine, a medication often prescribed for the treatment of high blood pressure, has not been specifically studied to date. Amlodipine works by dilating blood vessels, which lowers blood pressure, while psilocybin primarily acts on serotonergic receptors in the brain.
Although no direct interactions have been reported between amlodipine and psilocybin, psychedelics can affect heart rate and blood pressure. This can be potentially problematic for people who are already taking medication for cardiovascular disease or high blood pressure. Specifically, psilocybin can slightly increase blood pressure at the beginning of a truffle session, while it often lowers it somewhat after the session.
For these reasons, it is often advised not to take blood pressure-lowering medications such as amlodipine before using psilocybin. This reduces the risk of fainting and fainting. However, the half-life of amlodipine is long, averaging about 30 to 50 hours. This means that it may take some time for the medication to completely leave the body.
To calculate when amlodipine is completely out of the body, the five-times-half-life rule is often used. This implies that it takes approximately five times the half-life for a medication to be considered completely eliminated. For amlodipine, this would mean that it can take approximately 150 to 250 hours for the medication to completely disappear from the body. This corresponds to about 6 to 10 days.
Whether it is advisable to discontinue amlodipine for approximately a week prior to the truffle session must be assessed by the treating physician. The physician has more insight into the situation and may make changes to the medication, such as switching to another blood pressure lowering drug with a shorter half-life, so that the blood pressure lowering medication can be stopped closer to the truffle sessions.
More about: Truffle session| Psilocybin and medication use
