[Solved] Seroquel with psilocybin

The various recommendations you read may have to do with the fact that the combination use of Seroquel (Quetiapine) with psilocybin has not yet been properly investigated in practice. If Quetiapine (Seroquel) is prescribed for the treatment of psychotic disorders such as schizophrenia and bipolar disorder, the use of psilocybin is advised against. If Seroquel However, if prescribed for anxiety or as sleep medication, a psychedelic session with psilocybin might well be possible.

However, it is possible that Seroquel may reduce or influence the effects of psilocybin, but this has not been well studied. This is because Seroquel blocks activity at various dopamine and serotonin receptors, and psilocybin primarily affects serotonin receptors. Therefore, blocking serotonin receptors by Seroquel could lead to undesirable effects.

To prevent interaction with psilocybin and a reduction in its effects, it is better, if appropriate, to taper off Seroquel (Quetiapine) and wait at least 48 hours after the last dose before having a psilocybin session.

It is always important to discuss this with your treating physician before deciding to use psilocybin if you are taking the medication Seroquel. Your doctor can and may advise you based on your specific situation and may choose to taper off or stop your medication.

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