More info: Psilohuasca | Psilohuasca ceremony | Ayahuasca | Psilocybin

It difference between psilohuasca and ayahuasca lies primarily in the active ingredients used and the legal status.
Ayahuasca is a traditional shamanistic brew from South America that consists of two main ingredients: the Banisteriopsis caapi-plant (which contains MAO-inhibiting substances) and a DMT-containing plant such as Psychotria viridis or Mimosa hostilis. This combination causes DMT to become orally active and leads to a very intense and visionary experience. Ayahuasca is available in the Netherlands. illegal due to the DMT content, its use requires a strict diet, thorough medical screening, and extensive experience in guidance.
Psilohuasca is a modern and legal alternative that combines psilocybin-containing truffles or magic mushrooms with an MAO inhibitor such as Banisteriopsis caapi. The addition of an MAO inhibitor is not necessary for oral action with psilocybin, but is used to increase the duration and intensity of the trip. As a result, the experience resembles that of ayahuasca, but without the use of DMT. Although it is legitimate in the Netherlands, psilocybin also carries more risks than a pure psilocybin session, such as an increased risk of physical discomfort and more contraindications when using medication.
Psilohuasca has primarily become popular as an alternative to the banned ayahuasca. Nevertheless, warnings are issued against its use. Banisteriopsis caapi due to the physical side effects and interaction with medication. Many users therefore prefer the psiloflora ceremony, in which the MAO inhibitor Passiflora incarnata is used — a safer, calming alternative with comparable depth.
In summary: ayahuasca contains DMT and is illegal in the Netherlands; psilohuasca uses legal psilocybin and an MAO inhibitor to mimic a similar experience. However, due to the risks, psilocybin without MAOIs or in combination with passionflower (psiloflora) is increasingly being chosen to strike a balance between safety and spiritual depth.