Aside from the slightly increased risk in combination with medication use, the biggest disadvantage is that all psychedelics were criminalized in the past. This was done to continue suppressing the masses. By portraying psychedelics as something dangerous and legally prohibited, we can all become conditioned. If you now mention somewhere that you are going to eat magic mushrooms as medicine, you might be given strange looks. Acceptance is low, and that is currently the only real downside.

Do you want to know why and how we were lied to into finding magic mushrooms strange, while they are a natural medicine? Then check this out. YouTube video.