Meningeal monocytes and psychedelics such as psilocybin

Meningeal monocytes are immune cells located around the meninges. Under normal circumstances, they act as guardians at the border of the brain, but during chronic stress or inflammation, they migrate from the spleen and bloodstream to the meninges. There, they produce inflammatory substances that can have negative effects on brain regions such as the amygdala — crucial for the processing of fear and emotions. This inflammatory activity can contribute to the development or worsening of psychiatric conditions such as depression and anxiety disorders.

Psychedelic substances such as psilocybin and MDMA are able to suppress these harmful immune responses. In mice, it was demonstrated that psychedelics inhibit the migration of meningeal monocytes to the meninges and significantly reduce inflammatory responses. As a result, the level of anxious behavior decreases, despite exposure to chronic stress.

The effects appear to work indirectly via modulation of stress hormones, serotonin receptors on immune cells, and a decrease in pro-inflammatory cytokines. In humans, there is indirect evidence—such as an increase in the anti-inflammatory cytokine IL-10 after psilocybin use—that a similar mechanism is at work.

At psychedelic therapy This is addressed by not only placing the psychological experience at the center, but also focusing on the biological restoration of the brain-immune balance. The mechanism of action of meningeal monocytes may explain why some clients benefit long-term from just one well-supervised session. psilocybin session or truffle sessionIt is not only a mental reset, but also an immunobiological recovery response that brings long-lasting relief.

Would you like to know if your symptoms or situation qualify for this form of therapy? Then you can take the intake for trip therapy to fill in.