10 July 2024 16:24
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I take Normison and want to have a truffle session. Can I do that without stopping Normison?
23 July 2024 13:32
I take Normison and want to have a truffle session. Can I do that without stopping Normison?
Normison (temazepam) is a medication belonging to the group of benzodiazepines (the PAMs). These medications work by increasing activity on GABA receptors. GABA is a neurotransmitter in the brain that has an inhibitory effect on nerve cells. By enhancing the action of GABA, Normison ensures increased inhibition of nerve activity, resulting in relaxation, anxiety reduction, and promotion of sleep.
If Normison (temazepam) is taken in combination with truffles, the inhibitory effect of Normison will result in fewer effects from the truffles. To prevent reduced activity of the truffles, one may choose to stop using this benzodiazepine. The half-life of Normison (temazepam) is approximately 8-10 hours. This means that 40-50 hours (approximately 2 days) after the last intake of Normison, this medication will most likely no longer have an inhibitory effect on psilocybin from the truffles.
Always consult a doctor first to see if you can stop using medication. In most cases, a medication must be tapered off gradually.
More about: Truffle session | Psilocybin and medicines
1 Answer
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18 July 2025 18:31
Yes, in principle you can a psilocybin session do this if you use Normison (temazepam), but there are important considerations that determine whether it is wise to do that at that moment.
Normison is a benzodiazepine and has a calming effect via the GABA system in your brain. Psilocybin, on the other hand, stimulates the serotonin system (especially the 5-HT2A receptor), which leads to greater neuroplasticity, introspection, and emotional deepening. These two effects partially counteract each other.
What does this mean for you specifically?
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The effects of psilocybin are suppressed. if you still have Normison in your system. That means your experience may be flat or superficial, and you might be less able to access your emotions — precisely what psilocybin can be so powerful at.
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The combination is not physically dangerous., but the goal of a therapeutic session can be undermined.
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Ideally, you should not use Normison 48 to 72 hours in advance.. Then the medicine is largely out of your body, and you can experience the session optimally.
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Do you use Normison daily or chronically? In that case, it is strongly recommended to first consult your doctor about a tapering plan. Never stop taking benzodiazepines abruptly — doing so can lead to risks such as anxiety, insomnia, or even withdrawal symptoms.
What is the best thing to do now?
First fill in the intake form in. Based on your medication use, health, and goals, you will receive personalized advice from an experienced counselor. This way, you know exactly if you are ready for a psilocybin session, or that it is better to adjust your medication first.
If you like, I would also be happy to help you formulate a question for your GP or psychiatrist about temporarily stopping or tapering off.