We regularly receive questions via the forum about whether trip therapy is compatible with certain medications. For example, we are asked about:;
Can I do mushroom trip therapy if I use Bisoprolol fumarate?
Can Prozac and psychedelics be taken together, or do they also need to be tapered off?
Citalopram and substances such as magic truffles in trip therapy?
In trip therapy, we use psilocybin-containing mushrooms (psilocybin mushrooms) and sclerotia (magic truffles). Although psilocybin mushrooms and truffles are among the least harmful drugs, it is indeed important to take any other medication you are taking into account.

The image below clearly illustrates when we need to be careful about combining medication with ‘trip therapy’. The section on mushrooms can be regarded as ‘trip therapy’, as we use psilocybin, which is also found in magic mushrooms.

We cannot offer trip therapy whilst you are taking Tramadol. If you are taking it for a short period, you can stop immediately; if you are taking it long-term, you must taper off over a period of two weeks and then refrain from taking it for two weeks before starting trip therapy.
We do not recommend trip therapy for those taking SSRIs and MAOIs (MAO inhibitors), despite the low risk of complications. It is best to first undergo a tapering-off period* in combination with serotonin-boosting activities and diet or supplements. In this way, trip therapy can be a first step towards a medication-free life.
What isn’t mentioned, but needs to be pointed out, is that you must not take any psychedelics whilst on lithium. Lithium medication must first be tapered off* before a trip can take place.
* Coming off this medication can be a mentally draining process that requires support from a specialist. Always contact the person who prescribed the medication first.
In most cases, this does not pose a problem. Do bear in mind, however, that taking psilocybin raises blood pressure slightly. Ideally, you should follow a blood-pressure-lowering diet to reduce your reliance on medication and to further minimise the small risk of complications.
Benzodiazepines are ‘benzos’ or ‘pams’, such as diazepam, and are sedative medicines. This group of medicines carries a slightly increased risk and can make a trip less effective. The advice is to taper off them first, with the support of an expert.
Combining Triptherapie with cannabis, amphetamines and cocaine is unnecessarily dangerous, and we will never facilitate this. What is less dangerous is combining it with other substances such as alcohol and the physically debilitating GHB/GBL, and we do not do this either because it would defeat the purpose of trip therapy, which is to improve one’s health. Any form of unnecessary substance use should be avoided in the two weeks leading up to the trip therapy session in order to achieve the best results without posing any risks to physical and mental wellbeing.
Taking psilocybin on its own is very safe. When combined with medication or other drugs, there are only a few combinations that are genuinely unsafe. Nevertheless, it is wise to first wean yourself off medication by adopting a healthier lifestyle, and only then undertake a trip therapy session to tie up any loose psychological ends. Ultimately, your body is your most valuable asset. Take good care of it by looking after it properly.
We’re here to help. For example, you can get in touch via the forum, the comments below or via the email.
We’re often asked whether magic mushrooms are also drugs, and the answer is yes! Magic mushrooms are both party drugs and medication. Our ancestors used magic mushrooms in rituals, combined with music and the right guidance, to overcome mental health issues or to get through difficult times. Magic mushrooms have therefore been used as medicine for thousands of years.
Of course, you can also have a great time dancing on a small dose of magic mushrooms (triple level 1) or MDMA, which has roughly the same effect. If you use it as a party drug, it’s commonly referred to as a drug. If you use it according to our protocol, it’s a medicine.